Original articleInfluences of Cycloplegia with Topical Atropine on Ocular Higher-Order Aberrations
Section snippets
Patients and Methods
Subjects were recruited between September 2006 and March 2008 at the Miyata Eye Hospital. They were selected from consecutive cases among the clinic population who matched the inclusion criteria. Inclusion criteria were as follows: between 3 and 12 years of age, eyes with hyperopic refractive errors, best spectacle-corrected visual acuity (BSCVA) of 20/25 or better, and no ocular and systemic pathologic features except refractive error and ocular deviation (ocular misalignment or strabismus).
Results
Cycloplegia with topical instillation of 1% atropine solution for 1 week significantly increased spherical equivalent refraction from +1.92±1.53 D to +3.10±1.61 D (P<0.01, paired t test). Ocular HOAs significantly increased from 0.282±0.086 μm to 0.316±0.087 μm for coma-like aberrations (P = 0.02), from 0.169±0.058 μm to 0.192±0.076 μm for spherical-like aberrations (P = 0.02), and from 0.333±0.093 μm to 0.377±0.095 μm for total HOAs (P = 0.01; Fig 1). However, corneal HOAs did not change after
Discussion
As shown in the “Results,” spherical equivalent refraction significantly increased from +1.92±1.53 D to +3.10±1.61 D after cycloplegia, showing a mean positive shift of 1.18 D. It is known that cycloplegia inhibits accommodation during refraction and thereby prevents the overestimation of myopia and the underestimation of hyperopia.25 Even for an object at infinity, a certain amount of accommodation is present because of the balance between the sympathetic and parasympathetic innervation.26 The
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Manuscript no. 2012-11.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.