Original articleProspective Clinical Trial Evaluating the Efficacy of Photodynamic Therapy for Symptomatic Circumscribed Choroidal Hemangioma
Section snippets
Methods
This is a prospective, nonrandomized, multicenter clinical trial carried out in 10 centers in Spain. The trial started on January 12, 2005, and enrollment ended on October 25, 2005. The study protocol was approved by the Ethics Committees of all participating hospitals.
One eye from each of 31 patients was included in this clinical trial. The diagnosis of CCH was based on findings obtained by ophthalmoscopy, indocyanine green (ICG) and fluorescein angiography, and B-scan ultrasonography.
All
Results
The study included 17 men and 12 women with a mean age of 48.6±14.6. Presenting symptoms included blurred vision in all patients with a mean time from onset of 24.6 months. Metamorphopsia and scotoma were present in 58.6% and 48.3%, respectively.
Seven angiomas (24.1%) had been treated previously: 5 with laser (2 of these also with transpupillary thermotherapy) and 2 with transpupillary thermotherapy. The CCH was located at the macula in 68.9% (subfoveal 10.3%, juxtafoveal 24.1%, extrafoveal
Discussion
This study presents the only clinical trial and the largest prospective study reported to date of CCH treated with PDT. Regarding the natural history of this condition, the most complete clinical study of CCH is contained in the published reports of a group of patients from the Wills Eye Hospital. The latest report29 includes 200 patients, among whom 81% had exudative retinal detachment at the time of presentation. The clinical manifestations and factors predictive of final visual outcome are
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2020, Ophthalmology RetinaCitation Excerpt :The median interval for repeat treatment was 10.0 months in the current study. The retreatment interval was shorter in earlier studies (range, 1–6 months) for multiple reasons.8–11,13 Most of these studies were prospective with predetermined retreatment intervals, and flattening of the lesion was a key re-treatment criterion.
Long-term follow-up and “double layer sign” in patients affected by circumscribed choroidal hemangioma
2020, Photodiagnosis and Photodynamic TherapyCitation Excerpt :In particular, photodynamic therapy is a potent vaso-occlusive treatment, selectively generating intraluminal thrombosis at the endothelial membranes in specific vascular beds, while sparing the adjacent retina and retinal pigment epithelium-Bruch’s membrane complex [11]. Consistent with several previous studies, the results of our case series have confirmed that symptomatic circumscribed choroidal hemangiomas generally respond well to photodynamic therapy: 50 % of patients exhibited visual improvement [12,14,15,21–23]. At the final follow-up, the subretinal fluid had disappeared in the majority of patients (8/10; 80 %).
Manuscript no. 2008-288.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.