Original articleRisk Factors for Microbial Keratitis with Contemporary Contact Lenses: A Case-Control Study
Section snippets
Methods
This was a prospective case-control study with data collection during the 2-year period beginning December 3, 2003.
Results
The study design resulted in 367 cases and 2075 controls from 185 of 220 (84%) of Greater London postcodes (population of Greater London30 7 172 000) as well as from 241 UK postal districts outside London.
Table 3 shows the demographic data and the distribution of lens types and wear schedules for the 367 MK cases and the 2 different control groups included in the study. Another 241 CL users had corneal infiltrative events29 and were not included in this study. There were 77 hospital cases and
Discussion
This study measured the risks of MK, for the first time, for the DD soft CLs and silicone hydrogel lenses that have been introduced in the 10 years since the completion of the previously published epidemiologic studies on MK in CL wearers.1, 3, 4 The design of this study has provided the largest MK case series to date and a sample of patients from a large catchment area, which allows extrapolation of our findings to CL users in the United Kingdom and other similar environments. A limitation of
Acknowledgments
The authors thank the following steering committee members—O. Schein, D. Cavanagh, B. Holden, H. Taylor, D. Fonn, and J. McNally—for protocol and data review, and Dr Eric Beck, Ms Valerie Saw, and Ms Alison Mathews for reviewing the manuscript.
The authors were responsible for the design and conduct of the study; had access to and carried out the collection, management, analysis, and interpretation of all the data; and then undertook the preparation, review, and approval of the manuscript. A
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Manuscript no.: 2007-1401.
Financial Disclosure(s): None of the authors have any personal conflicts of interest.
Supported by the Institute for Eye Research, University of New South Wales, Sydney, Australia from a project grant made by CIBA Vision Corporation.