Journal of American Association for Pediatric Ophthalmology and Strabismus
Major ArticleFixation control and eye alignment in children treated for dense congenital or developmental cataracts
Section snippets
Subjects and Methods
Children treated for dense congenital or developmental cataracts during the first 5 years of life were enrolled following cataract extraction. Participants with cataracts were referred to the study by eight Dallas–Fort Worth area pediatric ophthalmologists. Excluded from participation were children with posterior persistent fetal vasculature, glaucoma, congenital infections, metabolic diseases, syndromes, and developmental delay. Children who experienced sight-threatening intra- or
Results
A total of 41 children were enrolled in the study. Age at presentation, age at surgery, age at outcome test, and visual acuity are provided for each child in e-Supplement 1 and e-Supplement 2 (available at jaapos.org). Of the 41 children, 20 had congenital cataracts and 21 had developmental cataracts (9 infantile and 12 with onset >12 months). Eye alignment and fixation control outcomes are also provided for each child in e-Supplements 1 and 2. Of the 20 children with congenital cataracts, 2
Discussion
There was a high prevalence of postoperative strabismus and nystagmus among children who had extraction of dense cataracts during the first 5 years of life. Congenital onset and visual deprivation >6 weeks were associated with significantly higher risk for strabismus; infantile onset and visual deprivation >6 weeks were associated with significantly higher risk for nystagmus. Congenital onset and unilateral cataracts were associated with higher risk for interocular asymmetry in amplitude or
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A dynamical method to objectively assess infantile nystagmus based on eye tracking. A pilot study
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2023, American Journal of OphthalmologyAmblyopia and fixation eye movements
2022, Journal of the Neurological SciencesCitation Excerpt :This might stem from the ease of calculations of BCEA that has resulted in its widespread use to quantify fixation instability in amblyopia. FEM waveforms and slow and fast FEM characteristics: Fixation instability arises from alterations in physiologic FEMs and the presence of nystagmus [23,26,28,30,105–110]. BCEA analyses alone do not readily identify the presence of nystagmus and do not provide quantitative parameters of different FEM abnormalities [24].
Current management of infantile cataracts
2022, Survey of OphthalmologyCitation Excerpt :Nystagmus and related fixation instabilities were also found in 60% of children who had interpretable recordings in both the contact lens group and the intraocular lens group in the IATS.256 Fusion maldevelopment nystagmus is found in many children with a history of congenital cataract and it is strongly associated with the infantile onset of binocular discordant input.257-259 Because reading relies on oculomotor function, specifically sequential saccades, it is conceivable that the binocularly disruptive influence of a unilateral infantile cataract could disrupt a child's ability to learn to read.257
Visual experience dependent plasticity in humans
2021, Current Opinion in NeurobiologyCitation Excerpt :Despite aberrant eye movements, visually orienting was observed in monkeys even after long epochs of visual deprivation [9,46]. However, it was only recently that visually guided eye movements were quantitatively assessed in CC individuals [47•]: Despite their prevailing nystagmus (which follows a visual deprivation of more than 8 weeks both in humans and in monkeys [9,48,49]) their goal directed eye movement achieved an astonishing accuracy (Figure 2). In fact, a comparison with patients suffering of infantile nystagmus due to other reasons than congenital cataracts indicated that differences in duration and accuracy between CC individuals and normally sighted controls were well explained by the superimposing nystagmus (Figure 2).
This work was supported by grants from the Gerber Foundation (EEB) and the National Eye Institute EY05236 (EEB).
The authors have no conflicts of interest to disclose.