TY - JOUR T1 - Effect of phenylephrine on static and dynamic accommodation JO - Journal of Optometry T2 - AU - Del Águila-Carrasco,Antonio J. AU - Lara,Francisco AU - Bernal-Molina,Paula AU - Riquelme-Nicolás,Resurrección AU - Marín-Franch,Iván AU - Esteve-Taboada,José J. AU - Montés-Micó,Robert AU - Kruger,Philip B. AU - López-Gil,Norberto SN - 18884296 M3 - 10.1016/j.optom.2018.01.005 DO - 10.1016/j.optom.2018.01.005 UR - https://www.journalofoptometry.org/en-effect-phenylephrine-on-static-dynamic-articulo-S1888429618300220 AB - PurposeWe tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics. MethodsWe performed two experiments to test the effects of PHCl on static and on dynamic accommodation in 8 and 6 subjects, respectively. Objective wavefront measurements were recorded of the static accommodation response to a stimulus at different distances or dynamic accommodation response to a sinusoidally moving stimulus (between 1 and 3 D of accommodative demand at 0.2Hz). The responses were characterized using two methods: one that takes into account the mydriatic optical effects on the accommodation produced by higher-order aberrations of the eye and another that takes into account only power changes paraxially due to the action of the ciliary muscle and regardless of the pupil size. ResultsWhen mydriatic optical effects were taken into account, differences in responses before and after PHCl instillation were 0.51±0.53 D, and 0.12±0.15, for static and dynamic accommodation, respectively, and were statistically significant (p<0.039). When mydriatic optical effects were not taken into account, the differences in responses before and after PHCl instillation were −0.20±0.51 D, and −0.05±0.14, for static and dynamic accommodation, respectively, and were not statistically significant (p>0.313). ConclusionsThe mydriatic effect of the PHCl causes optical changes in the eye that can reduce the objective and subjective measurement of accommodation. ER -