TY - JOUR T1 - Macular pigment spatial distribution effects on glare disability JO - Journal of Optometry T2 - AU - Putnam,Christopher M. AU - Bassi,Carl J. SN - 18884296 M3 - 10.1016/j.optom.2014.12.004 DO - 10.1016/j.optom.2014.12.004 UR - https://www.journalofoptometry.org/en-macular-pigment-spatial-distribution-effects-articulo-S1888429614001150 AB - PurposeThis project explored the relationship of the macular pigment optical density (MPOD) spatial profile with measures of glare disability (GD) across the macula. MethodsA novel device was used to measure MPOD across the central 16° of retina along four radii using customized heterochromatic flicker photometry (cHFP)at eccentricities of 0°, 2°, 4°, 6° and 8°. MPOD was measured as discrete and integrated values at all measured retinal loci. GD was calculated as a difference in contrast sensitivity (CS) between no glare and glare conditions using identical stimuli presented at the same eccentricities. GD was defined as [(CSNo Glare−CSGlare)/CSNo Glare] in order to isolate the glare attenuation effects of MPOD by controlling for CS variability among the subject sample. Correlations of the discrete and integrated MPOD with GD were compared. ResultsThe cHFP identified reliable MPOD spatial distribution maps demonstrating a 1st-order exponential decay as a function of increasing eccentricity. There was a significant negative correlation between both measures of foveal MPOD and GD using 6cycles per degree (cpd) and 9cpd stimuli. Significant correlations were found between corresponding parafoveal MPOD measures and GD at 2 and 4° of eccentricity using 9cpd stimuli with greater MPOD associated with less glare disability. ConclusionsThese results are consistent with the glare attenuation effects of MP at higher spatial frequencies and support the hypothesis that discrete and integrated measures of MPOD have similar correlations with glare attenuation effects across the macula. Additionally, peak foveal MPOD appears to influence GD across the macula. ER -